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Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

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In contrast, low stiffness increases the activity of the Ras-related GTPase RAP2 which inactivates RhoA and induces the phosphorylation of the large tumor suppressor kinase 1/2 (LATS1/2)