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3.2.3 Mechanisms of UPF and depression 3.2.3.1 UPFs and dysregulated lipid metabolism Several mechanisms have been proposed to link increased UPF consumption and depression risk (Figure 4

However, supplementation should be approached with caution, particularly for those with pre-existing conditions

A deficiency of the MTHFR enzyme is caused by mutations of the MTHFR gene (at least 40 mutations have been identified)

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