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B12 shots are also not recommended if you have a history of issues like leukemia, myeloma, or certain types of anemia not caused by B12 deficiency

Copper drives essential biological processes

in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis (44)

While high-dose B12 is generally safe, its still important to use supplements thoughtfully and pay attention to any unusual symptoms