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Extracellular matrix degradation and remodeling in development and disease

Natural killer (NK) cell activity, which helps fight infections, increased by 400% in the low-dose group and 210% in the high-dose group after 2 weeks

[PubMed] [Google Scholar] 38.Kipen HM, Fiedler N

The rationale is borrowed from other compounds where tissue saturation and receptor dynamics justify phased dosing