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The effectiveness of these new drugs will determine whether this pharmaceutical revolution meets its full promise

Medications such as valproic acid, cyclosporine, pivampicillin, and some anti-cancer drugs (e.g., etoposide, vinblastine) can also contribute to carnitine deficiency.[6] Valproic acid therapy may deplete carnitine stores by various mechanisms such as increased urinary excretion as valproylcarnitine, decreased renal tubular reabsorption, and decreased endogenous production

But berberine will also increase the effects of GLP medications

Carnitine octanoyltransferase (CrOT) is predominantly found in peroxisomes and plays a key role in the transfer of medium-chain acyl groups from the peroxisomes to the cytoplasm and mitochondria for further degradation [27]