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353 Conclusions Loss of astrocytic homoeostatic support is the primary mechanism underlying neuronal hyperexcitability in epilepsy and in migraine

PMID 15684413

and indirectly, as the essential co-substrate for glutathione peroxidase (GPx) and glutathione S-transferase (GST) enzymes that detoxify hydrogen peroxide, lipid peroxides, and electrophilic compounds

Among four flavonoids that were isolated from Apocynum venetum leaf, quercetin3-O-D-glucoside also showed anti-depressive activity with both gross changes (reduced immobility time) and biochemical alterations such as increased NE, DA, and 5-HT and reduced 5-HT metabolism (Yan et al., 2015)