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How This Works Retatrutide is a first-in-class triple agonist : it activates three of the bodys key metabolic hormone receptors at once GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and the glucagon receptor [1] [5]

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Justification for Compounding: Compounded GLP-1s are now largely only permissible under very specific, medically necessary circumstances (e.g., patient allergies to a specific excipient in the brand-name drug, or a dosage not commercially available)