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10.3389/fphys.2023.1323865 191 SponchiadoM.FaganA.MataL.BonillaA

These include cardiovascular responses (tachycardia, palpitations, elevated blood pressure), central nervous system symptoms (insomnia, restlessness, jitteriness, dizziness, tremors, headache), mood changes (euphoria or irritability), and gastrointestinal effects (dry mouth, unpleasant taste, constipation, occasional diarrhea)

It contains a small amount of benzyl alcohol, which helps inhibit bacterial growth and allows the solution to be used multiple times when handled correctly

Biologics are generally well represented across Phase I to Phase III, with peptide-based drugs among the most numerically dominant at each stage (Figure 3 b)