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Rather paradoxically, it has also been highlighted that GSHand notably its catabolites, as originated by metabolism by gamma-glutamyltransferasecan promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals

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FOXO4-DRI also alleviated endothelial senescence induced by oxygen-glucose deprivation (OGD) in vitro, enhancing endothelial cell function

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