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However, under conditions of stress and inhibition of the electron transport chain, the enzyme works in the opposite direction by transferring electrons from NADPH to NAD + , which impairs mitochondrial antioxidant defenses and feeds more reducing equivalents into the impaired electron transport chain leading to increased electron leakage and superoxide formation [133]
Indeed, VPA promotes the transport of glutamine through the mitochondrial membrane, thereby enhancing glutaminase activity
[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Kashtan CE, Ding J, Garosi G, et al
