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In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]

Also, NSAIDs, while lacking addictive potential, can cause a range of complications, such as upper gastrointestinal bleeding [23,66] and renal dysfunction [67,68]

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