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Werner syndrome is the most common accelerated-aging syndrome derived from DNA repair defects, caused by the mutations of Werner syndrome ATP-dependent helicase ( WRN ), a gene coding for a protein implicated in telomere maintenance and homology-dependent recombination repair (Osorio et al., 2011)

Autoimmune conditions, such as vitiligo and hypothyroidism, may promote premature graying

4 Combining ED, hospital, and poisoning databases, an estimated 450 deaths occur each year in the United States due to acetaminophen overdose, and approximately 100 of them are unintentional, primarily due to supratherapeutic dosing of child preparations

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