Pay in 4 interest-free payments of $5.62 Learn more
Ships within 48 hours · Estimated delivery Nov 8 - Nov 13
It is derived from a partial sequence of body protection compound (BPC), a protein naturally found in human gastric juice
Stroke and Excitotoxicity Protection Excitotoxicity protection appeared in stroke models where bilateral carotid artery clamping produces ischemia-reperfusion injury with massive glutamate release
5-Amino-1MQ Key Research Facts Chemical name: 5-Amino-1-Methylquinolinium (also abbreviated as 5A-1MQ or 5MQ) Target enzyme: Nicotinamide N-Methyltransferase (NNMT) Mechanism: Competitive inhibition of NNMT reduces 1-MNA production, preserves nicotinamide for NAD+ synthesis and SAM for epigenetic methylation Selectivity: High selectivity for NNMT does not inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes Membrane permeability: High passive and active transport permeability confirmed in PAMPA and Caco-2 cell assays NNMT expression: Upregulated in obese adipose tissue, multiple cancer types, and aged skeletal muscle tissue contexts of primary research interest Downstream targets: NAD+ availability, SIRT1/SIRT3 activity, SAM-dependent epigenetic methylation, lipogenesis, energy expenditure Pre-clinical models: Diet-induced obese (DIO) mice, 3T3-L1 adipocyte cell models, aged mouse skeletal muscle models, HeLa cancer cell lines In vitro cell viability: No impact on cell viability at 10 M concentration in 3T3-L1 pre-adipocytes in published toxicity profiling What Does 5-Amino-1MQ Do in Research
Combining regenerative therapies with nutrition, exercise, sleep optimization, and lifestyle modification often produces the most effective long-term results
US$ 21.25
US$ 25.41
US$ 22.60
.png)
