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2,6 The Australian evidence-based clinical guidelines for diabetes recommend GLP-1RAs as an add-on therapy in patients with cardiovascular disease, multiple cardiovascular risk factors or kidney disease, and intolerance or a contraindication to sodium-glucose cotransporter 2 (SGLT-2) inhibitors

Because these studies are observational (meaning researchers looked back at existing data rather than running controlled trials), they cannot prove that GLP-1s are neutral or protective for MS

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NICE guidelines recommend that statin therapy decisions should be based on a full cardiovascular risk assessment, not weight alone