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If a shake feels heavy halfway through, it stops being useful

Renal injury: Aortic cross-clamping and cardiopulmonary bypass create renal ischemia, leading to tubular mitochondrial damage, mtDAMPs release, and neutrophil-mediated tubular injury

doi:10.1056/NEJMoa1616011 31

However, if itching is severe, persistent beyond 4872 hours, or accompanied by spreading rash, significant swelling, or signs of infection, contact your GP or healthcare provider for assessment