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Because both peptides promote angiogenesis (new blood vessel growth), they are strictly contraindicated for anyone with an active malignancy or a history of cancer

In particular, in studies where only the 5 mM concentration of LC or ALC reduced infarct size significantly, prolonged drug administration could be a factor influencing the effectiveness of protection

Recent studies have revealed that CYP11A1-mediated metabolism of Vitamin D and lumisterol in the skin generates novel secosteroids, which not only activate the Vitamin D receptor (VDR) but also bind to other nuclear receptors such as ROR, AHR, and LXR, exhibiting multi-target biological effects [108]

KPV's primary research literature focuses on mucosal inflammation and gut epithelial protection, with some documentation in skin wound models