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[2] Dsledkom aktivcie GLP-1 receptora je aktivcia adenyltcyklzy, zvenie intracelulrneho cAMP, o aktivuje proteinkinzu, zvi sa cytoplazmatick koncentrcia vpenatch inov a v pankreatickch bunkch to vyvol degranulciu buniek za uvonenia inzulnu

Antagonista GIP - agonista GLP-1: MariTida Este frmaco (Maridebart-cafraglutida o AMG133), que es un conjugado de un anticuerpo monoclonal frente al receptor de GIP y dos molculas de agonista del receptor de GLP-1, es eficaz en reducir el peso corporal en ratones y monos cinomolgus con obesidad

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Patients generally experience a significant reduction in cravings and find it much easier to manage choices around food (i.e