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(2) Synthesis of the isoprenoid tail: The isoprenoid tail of CoQ is synthesized through the cytosolic mevalonate pathway, which produces key precursors such as isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) 28,31

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Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial