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For instance, tissue apical exposure to Chlorocresol failed to induce a CBF decrease in MucilAir-HF tissues, and LPS via apical exposure did not trigger intense inflammatory cytokine secretion in EpiAveolar model, whereas a mild response was observed in MucilAir-HF tissues exposed to TNF- and LPS (at 6h/day aerosol exposure only)

Cell Death and Differentiation , 31 , 16641678

In fact, a 2023 paper published in the Journal of Cerebral Blood Flow & Metabolism reported that methylene blue (in similar doses studied by researchers at The University of Texas at Austin who claimed the compound had memory-enhancing properties) led to a 8% decrease in human brain blood flow

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