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Further demonstrating the therapeutic potential of targeting glycolysis, the natural compound derivative D5, sourced from Radix Aucklandiae, attenuates colitis in mice by impeding the nuclear translocation of PKM2 dimers, thereby suppressing glycolytic flux and Th17 cell differentiation (211)

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It may be argued that radical scavenging by hydropersulfides is nevertheless limited by their inherent instability, as they are subject to thiol-mediated reduction in the presence of millimolar amounts of GSH (GSSH + GSH GSSG + H 2 S)