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Similarly, cisplatin, a chemotherapy chemical, caused toxic complications of autophagy and cell death in mouse renal tubular epithelial EpiCM-a cells through ERK1/2 activation, whereas aristolochic acid I attenuated cell apoptosis through pERK1/2-mediated autophagy activation in rat RTCs (NRK-52E) 41

Considering the mechanistic overlap in the development and progression of CKD in type 1 and type 2 diabetes, there exists a strong rationale for simultaneously developing novel CKD therapies for use in both type 1 diabetes and type 2 diabetes and studying the repurposing of existing type 2 diabetes CKD therapies for the treatment of CKD in people with type 1 diabetes

Yet, more and more people started using it even without a medical indication

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