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The BALANCE model (CMS) allows additional states to opt in starting May 2026

GLP-1 receptor agonists have reshaped how clinicians and researchers think about metabolic disease, revealing a hormone system that links appetite, reward, emotion, inflammation and cardiovascular health

Retatrutide appears to have a similar safety profile to other GLP-1 medications: No increased risk of pancreatitis in trials so far No hepatotoxicity signals (liver damage) No cases of ketoacidosis Serious adverse events were rare (2.5% of participants) The trials are ongoing, so we'll learn more about long-term safety

Better blood sugar control in individuals with insulin resistance