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doi:10.1038/s41401-020-0413-7

Despite not being a primary aim of the study, by collecting participant characteristics we saw clinically significant improvements in physical health (weight and HbA1c), of similar magnitude to that seen in trials of GLP-1 receptor agonists in obesity [35] and T2D and overweight [36, 37]

Clinical use of DPP-4 inhibitors

Classic examples include native GLP-1, which has a plasma half-life of approximately 2 minutes and required continuous infusion in early studiesan impractical route for chronic therapyyet was subsequently transformed into a once-weekly therapeutic through lipidation and albumin-binding strategies ( Third, pleiotropic signaling that aligns with physiological function rather than nonspecific toxicity favors re-evaluation