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Accessed March 18, 2020

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Contrasting with these growth-inhibitory actions of IGFBPs, there is also clear evidence of growth promotion by IGFBPs in both cancer and non-cancer cells, as well as extensive clinical data linking high IGFBP expression in a variety of cancers to a more aggressive phenotype and poor patient survival [17]

Genetic variation in cytochrome P450 enzymes affects how each person metabolizes berberine, making personalized assessment critical