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When high levels of oxidative stimuli are present, additional sets of intracellular signaling cascades are triggered that are potentially proinflammatory

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This explains why the daily pill requires a 25 mg dose compared to the weekly 2.4 mg injection, and why individual drug exposure levels can range from 27 to 186 nmol/L on the oral form versus a tighter 51 to 110 nmol/L range with injections

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