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So, staying alert about these special issues helps keep people safe when using this drug

Practical Mitigation Strategies Start low and increase it gradually to minimise GI upsettitrate semaglutide from 0.25 mg weekly, increasing gradually every 4 weeks

There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)

The primary composite endpoint (cardiovascular death or worsening heart failure) was reached in 9,9% of the tirzepatide arm versus 15,3% of the placebo arm (HR 0,62, p=0,026)