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The consequence of T cell activity in AD appears to be predominantly detrimental, as T cells secrete IFN- and TNF, which further activate microglia to a neurotoxic phenotype and directly induce neuronal death or synapse loss
This adds to the growing body of evidence that G protein-favouring biased GLP-1RAs typically show reduced efficacy for recruitment of both G proteins and tins (Lucey et al ., 2020
