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However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans

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Both peptides have been studied in human trials, and their mechanisms of action are well characterized

Potential risk Level of risk: Negligible Copper peptides are generally well tolerated by the skin, but mild irritation or allergic reactions may occur at high concentrations or in sensitive skin