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A metabolome analysis disclosed that sulphasalazine triggers an increase in the glutamate-derived TCA cycle intermediate -ketoglutarate in addition to a decrease in cysteine and glutathione

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Arch Biochem Biophys 373: 193202 ColombiniM (1989) Voltage gating in the mitochondrial channel, VDAC

Research published in the Indian Journal of Clinical and Experimental Dermatology indicated that 54% of dermatologists who administer glutathione feel there is not enough safety data to reliably recommend frequent IV usage