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In translational research strategies evaluating antiarrhythmic concepts to be applied in patients with paroxysmal AF or following rhythm control by ablation or cardioversion, the use of cells obtained from subjects with persistent or even permanent AF exhibiting different cellular electrophysiological mechanisms constitutes a limitation that requires careful consideration

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Serum B12 above 300 pg/mL is often interpreted as normal (6) Serum B12 levels between 200 and 300 pg/mL are considered borderline (in which case further enzymatic testing may be helpful for diagnosis) (6) Enzymatic testing: serum levels of MMA and homocysteine should both be elevated if B12 deficiency is present