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When to Contact Your Healthcare Provider Contact your doctor immediately if you experience any of the following: Severe swelling or hives - could signal an allergic reaction to copper or the diluent Dark urine or yellow eyes - possible copper-induced liver stress Numbness or tingling in hands/feet - may indicate nerve irritation from excess copper Persistent nausea or metallic taste lasting more than 24 hours Sudden hair shedding spike instead of regrowth after month 2 Signs of infection at the injection site: spreading redness, warmth, pus Mood changes or depression