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Nature 407, 762764

This formulation protected probiotics from gastric stress, enabled controlled intestinal release, improved colonic delivery, restored mucus secretion, reinforced tight junctions (occludin, ZO-1), and enriched beneficial bacteria (genus Lacticaseibacillus , species L

[15] Methodological issues with the clinical trials prevent firm conclusions, and the review authors stated: "No definitive conclusion can currently be drawn" and there is "no definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee." [16] Contraindications and safety [edit] In July 2007 a manufacturer of MSM submitted a notification to the U } : CS1 maint: DOI inactive as of July 2025 (link) Oyo Yakuri Pharmacometrics

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