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You can expect an appointment for a Full Bag treatment to take 90 minutes, and an appointment for a Half Bag treatment to take 60 minutes

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Due to premature termination, steady-state could not be achieved for the 3.0 mg/day cohort and AUC 0-inf for both 1.5 mg/day and 3.0 mg/day cohorts could not be estimated

Acknowledgments This work was supported by the National Natural Science Foundation of China (grant 81670336) and the Wenzhou Grant for Scientific Talents (RX2016003), Wenzhou Science and Technology Bureau