That is double your starting dose, which may trigger significant gastrointestinal side effects including nausea, vomiting, and diarrhea
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By engaging all three receptors simultaneously, retatrutide aims to suppress appetite, regulate blood sugar levels and increase the body's metabolic rate and help increase energy expenditure and influence fat metabolism, though the exact contribution of each pathway is still being studied
doi:10.1056/NEJMoa2301972 Sanyal AJ, Kaplan LM, Frias JP, et al