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Virus-induced hyper-inflammation with complement activation in kidney tissue could inflict focal segmental glomerulo-sclerosis with glomerular involution and lead to AKI 138

In a large cohort study, nearly all cases of initial thyrotoxicosis evolved late hypothyroidism, with overt thyrotoxicosis occurring a median of 5 weeks after the first ICI dose and overt hypothyroidism developing a median of 14 weeks later (Muir et al

However, acute toxicity may occur at high exposure levels near or exceeding the LD 50

doi: 10.3389/fpls.2014.00442 Received 24 June 2014 Accepted 18 August 2014 Published 09 September 2014 Volume 5 - 2014 Edited by Nicole Linka, Heinrich-Heine Universitt Dsseldorf, Germany Reviewed by Viktor Zarsky, Charles University, Czech Republic