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Transcript: Most often, [members of] the oncology team are not the ones initiating a GLP-1 agent because the indication is obesity and diabetes, so these agents are being initiated by their primary care doctors, endocrinologists, etc

Although the modulation of transcription through histone modification serves as a useful paradigm, the mechanisms that mediate the anticancer effects of HDIs are more complex, with many non-histone targets identified (Figure 2)

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If side effects are significant, your provider may recommend remaining at your current dose for an additional week or two before escalating, or in some cases, temporarily reducing the dose