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In this study oxidative stress parameters other than GSH such as SOD and catalase were found to be decreased, whereas glutathione peroxidase (GSH-px), tyrosine hydroxylase (TH), and malondialdehyde (MDA) were increased in melasma subjects compared to controls

559 In contrast, silencing of this gene in astrocytes in global SOD1 expressing mice with ALS-like symptoms, arrested pathological progression

Collectively, these observations support that mitochondrial dysfunction (particularly the MPT theory) is present in human -cells although further investigations are required to establish if lipotoxicity is the cause