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Key enzymes involved in glutathione biosynthesis and recycling were upregulated, including Gclc and Gclm (which form the rate-limiting enzyme glutamate-cysteine ligase), and Gss (glutathione synthetase)

This shift in cellular chemistry is associated in rodent studies with altered substrate utilisation

Key priorities include doseresponse optimization for acute versus chronic phases, inclusion of biomarkers such as glutathione reductase activity, neuroinflammatory cytokines, and imaging-based lesion metrics, and development of formulations that improve central nervous system bioavailability