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It requires a commitment on part of the patient to realize all the beneficial effects

33,34,35,36,37 One study suggests that length of time from diagnosis of cognitive impairment is important for response rate, in that patients who had experienced symptoms for less than 12 months improved on B12, whilst those with symptoms for more than 12 months continued to decline

CML progenitors are CXCR4-deficient: Restored expression after interferon alpha or tyrosine-kinase inhibitor treatment in vivo