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Farkas I, Vastagh C, Farkas E, Balint F, Skrapits K, Hrabovszky E et al (2016) Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways

A 2022 real-world analysis of GLP-1 prescriptions (N=14,200) published via the NIH National Library of Medicine found that patients who spent at least six weeks at each dose step had a 34% lower discontinuation rate in the first six months compared with patients who escalated every four weeks [4]

It describes that baseline assessment as foundational to realistic goal-setting and adherence planning, and says it can also inform provider decisions about the treatment plan

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