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102 In addition, despite increased urinary excretion of 1-microglobulin has been reported in patients undergoing myocardial revascularization surgery with cardiopulmonary bypass, 103 and the increases were greater with longer duration of cardiopulmonary bypass, 104 it was shown that preoperative but not postoperative urinary 1-microglobulin levels were positively associated with acute kidney injury, progressive chronic kidney disease, and all-cause mortality after cardiac surgery

Emerging studies using CSF and advanced neuroimaging techniques, such as brain magnetic resonance spectroscopy (MRS) are beginning to uncover neurobiological changes that may further elucidate disease mechanisms

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No Reported Event Equals Safe Very small studies may be incapable of identifying uncommon, delayed or population-specific risks