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Caffeine regulated four inflammation-related signaling pathways (Toll-like receptor signaling, JAK-STAT signaling, NF-kappa B signaling, and Th17 cell differentiation) and seven metabolic signaling pathways (glutathione metabolism, PPAR signaling, phagosome, PI3K-Akt signaling, insulin signaling, fructose and mannose metabolism, and AMPK signaling) that were not regulated by EGCG (Figure 8A, left side of orange box)