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The aspartic acid residue is highly susceptible to dehydration, forming a cyclic imide that can then hydrolyze into either the original form or an inactive iso-aspartate analog

Las enzimas citoslicas de la fase I comienzan la detoxificacin y, posteriormente, la GSH (enzima de fase II) realiza una conjugacin y origina un xenobitico que puede difundirse a travs de la clula para su excrecin mediante una bomba transmembranal activada por la ATPasa

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For a detailed summary of all model equations, steady-state constraints, observation functions and model parameterization see Supplement