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N Engl J Med 2025;393:26-36)

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If your primary prevention patient is high-risk via the PREVENT-ASCVD equations, the new target is less than 70 mg/dL

A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)