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A useful comparison point is the acylation chemistry described for semaglutide by Lau and colleagues in the Journal of Medicinal Chemistry in 2015 [2], which introduced a C18 diacid linked through a spacer to achieve albumin binding on a GLP-1 scaffold

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In a recent study of 28,315 patients with incident T2D, around half of patients spent the 10 years after diagnosis with HbA 1c above desired targets: mean percent time spent with HbA 1c 7% was 40% in the first 2 years and 61% after 610 years (3)

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