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In a randomized, placebo-controlled trial of 20 obese, insulin-resistant adults, 4 weeks of TUDCA (1,750mg/day) improved hepatic and muscle insulin sensitivity but did not reduce liver fat.6 There are no completed human trials showing TUDCA improves NAFLD histology or imaging

Consequently, the targeted inhibition of GOT1, in conjunction with its upstream and downstream pathways, or the combined inhibition of the major metabolic pathways of glutamine, has emerged as a promising novel strategy to overcome metabolic therapy resistance

Few, if any, studies have explored the possibility of low GSH levels as a potentially important causative driver of disease pathology in itself [21]

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