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Synthesis of ROS-sensitive polymers (P1) To a solution of 1 h,1 h,10 h,10h-perfluoro-1,10-decanediol (0.62 g, 1.35 mmol) and ROS sensitive molecular (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 mL), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.63 g, 2.83 mmol) was quickly added

Patient and public involvement (PPI) was undertaken during study preparation to assess the clarity and acceptability of participant-facing materials

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Goal: Support cellular energy metabolism, mitochondrial function and DNA-repair pathways by replenishing NAD+ goals pursued in research and wellness, not established for injectable NAD+ in humans [5] [6]