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To date, cabozantinib (Cabometyx and Cometriq, Exelixis Inc., San Francisco, USA) and crizotinib (Xalkori, Pfizer, New York, USA) are the only c-MET inhibitors that have received US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approval in selected cancer types (Table 1) [1116]

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