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12-15 Cymbalta side effects when taken long term can include: Addiction Dependence Seizures Suicidal thoughts or behaviors Mania, hypomania Jaundice Liver failure Abnormal bleeding, especially when NSAIDs or aspirin are taken concurrently Severe renal impairment Urinary hesitation, and retention Hyponatremia (low sodium levels in the blood) Severe weight gain Cardiotoxicity issues: tachycardia, QT prolongation, blood pressure issues Brain fog Agitation Fatigue Low sex drive Constipation Diarrhea While Cymbalta is advertised to help those dealing with severe depression, anxiety, or pain, its list of serious and life-threatening side effects may drastically outweigh any actual benefit

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244 Adverse effects have included gastrointestinal symptoms, dose limitations, and electrocardiographic abnormalities, such as prolonged QT intervals