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10.1038/nrm3877 37 NarendraD.TanakaA.SuenD

The 28-day rule United States Pharmacopeia (USP) general guidelines indicate multi-dose vials containing preservatives such as benzyl alcohol may be used for up to 28 days after the initial puncture, provided they are stored properly and free from visible contamination

69 Potential mechanisms include decreased intestinal lipid production, reduced intestinal triglyceride absorption due to lowered secretion of apoB48-containing chylomicrons, smaller postprandial triglyceride secretion and effects on the expression of genes involved in lipid metabolism

Wissmann, M